The major difficulty for using shadow information is due to the complicated lighting conditions in indoor environments.
However, the normalizing part Z is also a function of θ, which is the main difficulty for using the MLE method directly.
However, it is a huge and complex database and there are some important methodological and technical difficulties for using it due to its volume and architecture.
People with multiple physical and cognitive impairments have difficulties for using properly conventional pointing devices, what reduces their possibilities to communicate and improve their cognitive and physical skills through computers.
Thus far, a comprehensive food composition database of lignans is lacking, resulting in significant difficulties for using traditional instruments to accurately quantify lignan intake.
This study highlights potential difficulties for using Q-PCR as a validation tool for transcriptome analysis in the presence of sequence polymorphism and emphasizes the need for extreme caution and thorough primer testing when assaying genetically diverse biological materials such as Pacific oysters.
Research has identified issues preventing their mainstream adoption to be, among others, the gap between PSS supply and demand (Geertman, 2016), their difficulty of use, a need for greater understanding of PSS capabilities and a lack of awareness of their applications (Russo et al., 2017; Vonk, Geertman, & Schot, 2005).
The greatest difficulty for the use of the lignocellulosic residues is represented by the physical barrier formed by the lignin, which prevents the use of the native cellulose; thus the enzymes cannot penetrate this barrier easily.
Koshihikari is a valuable genetic resource for good eating quality, but its long culm and susceptibility to rice blast disease have often caused difficulty for its use as a parent.
Another difficulty for the use of EMP as biomarker in the critically ill is the possible interference with lipid-rich solutions [ 45].
9 The difficulty of using cytokines for elderly patients is well established; nevertheless, it has been reported that the efficacy still remains, even with a decreased dosage of cytokines, so bevacizumab seems to be a good drug for elderly patients.
