However, high cost, long time consumption, extensive effort, and in some cases irrevocability are the main challenges and difficulties for developing ubiquitous systems.
However the difficulties for developing web-based application programs are that there can be the numerous unspecified users to access the application programs.
One of the difficulties for developing a theory of series solutions to nonlinear equations on time scales is that the formula for multiplications of two generalized polynomials is not easily found.
One of the difficulties for developing the philosophy of dance is that the methodology of philosophical analysis encourages separating out each art form in order to say what makes it distinct from every other form of art.
On the other hand, the ideational metaphor types suggested by the semantic model create difficulties for developing an approach to teaching GM due to its delicacy and complexity consisting of thirteen major types.
From the first application of TILLING to Arabidopsis [ 23], many studies have detailed the difficulty of developing primers for TILLING and EcoTILLING for crops, because most crops harbour very complex genomes and genomic sequence information is insufficient [ 10, 20, 24, 25].
The effects of post-transcriptional and translational regulation of signaling can increase the difficulty of developing methods for individualized mechanism-based therapeutic interventions.
The relative scarcity of SNPs in cultivated allotetraploid cotton reflects the difficulty of developing SNPs for its complex genome, comprised of large repetitive regions and homeologous content due to recent polyploidization.
Recognition and understanding of physicians' challenges when treating diabetes patients' social and emotional difficulties are important for developing programmatic interventions.
Understanding how physicians perceive the severity and consequences of patients' social and emotional difficulties is important for developing solutions for these problems.
The secretin story shines a light on the difficulty of developing a drug for autism, an often debilitating condition whose incidence seems to be rising sharply and for which there are no approved drugs.
