A large gap of rheological properties between the raw and pretreated lignocellulose raised a difficulty for designing proper pretreatment reactors with maximum efficiency and minimum power consumption.
Another difficulty for designing predictable behaviour in interconnected modules is the fact that different connected modules might have varying sensitivity to the intra- and intercellular environment.
The lack of knowledge about particle behavior in combined sewer detention tanks remains a significant difficulty for the design of these works.
However, exchanges inside the spray mixture are difficult to express as combined mass and heat are transferred between phases, resulting in difficulties for the design of spraying systems.
Two coalescent kettle holes at Borras Bog constitute a natural obstacle on the route of the A5156 Llanypwll Link Road and posed difficulties for highway design and construction.
These rigid inclusions can significantly change the entire stress distribution in the membrane and therefore create major difficulties for the design.
If (10) is fulfilled, the feedback AD in Fig. 4 produces two unstable poles in the open-loop transfer function from i ref to i L1 or i L2, yielding some difficulties for robust design [27, 31].
The most characteristic features of MOOCs massification, heterogeneity and the absence of a tutor, differ entirely from online academic training, and these extreme training characteristics present greater difficulties for the design of MOOCs than for other online courses (Fidalgo-Blanco, García-Peñalvo & Sein-Echaluce, 2013).
Exons show very little variability for the phylogenies of closely related species, whereas intergenic regions present difficulties for the design of primers of wide-specificity.
However, the difficulty of designing handles for the specific attachment of the different ends of polysaccharide chains to substrates, such as piezoelectric scanners, cantilevers or microbeads; particularly in contrast to nucleotides and proteins, has meant that progress in more sophisticated single carbohydrate measurements has been relatively slow.
