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The literature is replete with reviews describing a status quo of relative ease of QTL identification and great difficulty discovering the underlying polymorphism (e.g., see [ 1]).
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In the case of the difficulty discovered by Burali-Forti, the consequence for Cantor was that the multiplicity (Mannigfaltigkeit) of ordinal numbers is itself well-ordered, but is not a set: hence, no ordinal can be assigned to it, and the antinomy is resolved.
A heterogenic group of patients was also a methodological difficulty discovered, since this interferes in the physiopathological analysis of the individuals submitted to exercise.
In addition to this difficulty of discovering SNPs are the difficulties of SNP scoring in a tetraploid genome.
Restrictions on advertising "serv[e] to increase the difficulty of discovering the lowest cost seller..
One difficulty is discovering what people would be willing to spend.
"Many users may have difficulty even discovering what functionality and/or information is available on their electronic devices or on various websites," reads part of the filing.
As Russell himself put it in 1909 "the difficulty of discovering the truth does not prove that there is no truth to be discovered" (Philosophical Essays: 20/Papers 6: 20/Papers
Their respective effect may be masked or enforced by another, which increases the difficulty in discovering the underlying relationship between them (Feng et al. 2014).
This change of strategy was provoked by the increasing complexity and difficulty of discovering and developing new drugs and by skyrocketing drug-development costs.
Plaintiffs will encounter at least three substantial deterrents: expense, time, and the difficulty of discovering substantial incriminating evidence before a complaint is even filed.
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