Sentence examples for difficulty and limit from inspiring English sources

These individual differences in response to each agent highlight the difficulty and limit of treating multifactorial disease by targeting single cytokine or single cell type.

The main difficulty and limit of these models is the estimation of standard deviations which were obtained by Monte-Carlo simulations associated with bootstrap re-sampling.

Important difficulties and limits of this approach are the shared control with the driver on the steering wheel and the vehicle handling at limits.

Losing productive assets reduces the earning potential of households, leading to the perpetuation of difficulties and limiting the opportunities for recovery.

B cell subpopulations in the spleen have been extensively characterized phenotypically; however, biochemical properties of these cell populations following B cell antigen receptor engagement have not been fully determined due to technical difficulties and limiting cell numbers.

Instead of dedicating time to fixing the defect, Alcorn decided it gave the game more difficulty and helped limit the time the game could be played; he imagined two skilled players being able to play forever otherwise.

Children who are exposed to violence may have difficulty learning and limited social skills, exhibit violent, risky or delinquent behaviours or suffer from depression or severe anxiety.

An early active individualised psychosocial support (APAPI) would enable, in our opinion, help to be provided for the patients facing the greatest social and psychological difficulties and so limit the consequences of their disease on their work and generally speaking improve their quality of life.

Continuous renal replacement therapies use a slow blood flow rate, necessitating anticoagulation and prolonged treatment times that may create difficulties with staffing and limit patient diagnostic and therapeutic procedures.

The inclusion of images within printed examination papers is now technically possible, but data regarding their effect on psychometric item properties, such as difficulty and discrimination, are limited [ 19, 45].

These systems will be described in relation to the technical issues, engineering difficulties and physical limits involved.