Sentence examples for difficulty and expense from inspiring English sources

They can be replaced only with great difficulty and expense.

Analysts said these arrangements were wise, given the difficulty and expense of running e-commerce operations.

The difficulty and expense of mapping these spaces is a major barrier to storytelling for science, conservation, and stewardship.

This allows initial screening of candidate coatings without the difficulty and expense of testing in an actual gun or in a vented combustor.

Given the difficulty and expense of landing spacecraft on the moon and Mars, President Obama has talked repeatedly about a manned mission to the asteroids by 2025.

Most recently, the developers began looking at an alternative, after assessing the difficulty and expense of building over an active train station.

The increasing difficulty and expense involved in getting public documents has been a matter of concern to the American Society of Newspaper Editors for months.

"That whatever the Soviet Union did at enormous difficulty and expense, in principle can be done cheaply and easily with modern technology".

Despite their promising attributes, significant pharmaceutical issues, including poor tissue distribution, systemic toxicity, and difficulty and expense of manufacturing, have severely hampered clinical progress.

However, with its inherent difficulty and expense, experimental characterization of function cannot scale up to accommodate the vast amount of sequence data already available1.

This is particularly relevant to the topic of biodiversity because of the difficulty and expense of assessing the impact of any given entity.