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Since siRNA application presents clinical difficulties, we thought that inhibitors targeting the signaling proteins might block the HSR pathway and achieve the same goal.
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But if we can just get people to think a little more about medical value and the difficulties involved, we think we have done a good job," Lee says.
Anticipating the cultural norms, we thought women would face difficulty in expressing their views in front of men (31).
The difficulty with that we think is it would tend to drive them (landlords) out of the market".
The difficulty arises when we think about how to craft advisories for fish with intermediate levels of MeHg and PUFAs, including tuna, snapper, bluefish, sea bass, freshwater bass, pike, and walleye.
Julie Hudson at UBS said: "Should transport emissions become too difficult to regulate because of the difficulty of amassing accurate data, we think this might go way beyond the diesel engine, to accelerate the demise of the combustion engine".
"It is very difficult to distinguish [Neilson's claim] from the specification of a patent for a principle, and this at first created in the minds of some of the court much difficulty; but after full consideration, we think that the plaintiff does not merely claim a principle, but a machine embodying a principle, and a very valuable one.
This difficulty can be overcome if we think of the receptacle as filled space.[16] As space, its role is to provide both three-dimensional extension and a specific location for any observable particular to be "in" at a given time: for any particular to be, it must be occupy some spatial location (52b3 5), though not necessarily the same one throughout.
We think the difficulty lies in the following aspects: (i) text classification for 40 000 classes is much more difficult than binary classification task.
Team boss Martin Whitmarsh said: "I firmly believe we have the drivers, car and team to win both titles - and I think the difficulties we encountered during the first 10 races of 2012 have strengthened our resilience and hardened our resolve to fight back to the front.
"And in spite of the difficulties, I think we are much better off".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com