This is one difficulty to further study the problem on step-like contrast structures.
An alternative (but not mutually exclusive) explanation is that the upregulation of the male X in stratum II (fig. 3) may lead to a lack of resident male-biased genes due to the inherent difficulty to further increase transcription in the male X copy (assuming that transcription rates are limited) (Vicoso and Charlesworth 2006, 2009).
The opposition, instead of rallying behind the crown, exploited its difficulties to wrest further powers so as to be in a position to take charge once the war was over.
However, we do remind them of the need to continue to address their interpersonal difficulties to make further progress with regards to the eating problem.
Some experimental and theoretical difficulties specific to further generalization of the theory of overpotential buildup and decay processes are outlined, and the manner in which the coverage variation with overpotential could influence the measured stoichiometric number is briefly discussed.
But Milbank's column demonstrates how these difficulties can lead to further difficulties: In his zeal to minimize the gravity of the issue, he's ended up strongly implying something I'm pretty sure (and hope!) he didn't mean to say.
The limited sampling time was due to technical reasons, namely the difficulty to perform further blood collection at fixed time points during recovering from general anaesthesia in field conditions.
And from the engineer's perspective, they write, making robots "sensitive to moral considerations will add further difficulties to the already challenging task of building reliable, efficient and safe systems".
The unusually ultra-deep and ultra-high-pressure gas reservoirs in the Keshen 8 Block on the Kelasu structural belt of the Tarim Basin are also featured by high temperature, well-developed fault fissures, huge thickness, tight matrix, complex oil water distribution, etc., which brings about great difficulties to reserves evaluation and further development.
Cryotherapy adds further difficulties to the measurement procedure, for example, a limited data acquisition time after the cold application.
