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The difficulties pertaining to both rationalism and empiricism have led many epistemologists to think that there must be something fundamentally wrong with the way in which the debate has been framed, prompting their rejection of the foundationalist justificatory structure underlying rationalism and empiricism alike.
Until recently, limited information has been available regarding mechanisms modulating miRNA expression during malignant transformation, primarily due to difficulties pertaining to identification of promoters and transcription start sites (TSS).
A decade ago editorial attention in the Lancet was paid to the conceptual and methodological difficulties pertaining to the concept of QoL [ 13].
Cognitive interviews can indicate the existence of problems with questions, for example, difficulties pertaining to a particular recall period or to the mode of administration.
To overcome difficulties pertaining to the imbalance in the tumor cell apoptotic pathway, we therapeutically targeted cells that present normal levels of the BCL-2 relatives, the endothelial cells.
Being a 'difficult patient' is further dependent on a spectrum of difficulties pertaining to the patient himself, such as poor illness perception and understanding (resulting in undertreatment or overtreatment), smoking habits/lifestyle/behaviour, poor intelligence, poor compliance, old age and bad quality of life/poor economy.
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A difficulty pertaining to theories of coherence that construe coherence as a multidimensional concept is to specify how the different dimensions are to be amalgamated so as to produce an overall coherence judgment.
Responders rate the level of difficulty pertaining to each item on a 5-point Likert response format, generating summative scores for each domain.
This process is often difficult, as it must take into account the extensive understanding of specific difficulties, sometimes pertaining to local factors affecting HCW attitudes.
Many participants had difficulties answering questions pertaining to frequency of visits to the general practitioner (26%), time spent receiving healthcare services (39%), regular medication currently taken (35%) and out of pocket expenditure on medication (42%).
Several factors have hindered the advancement of endostatin- and angiostatin-based therapies, such as short serum half-lives, manufacturing difficulties, and issues pertaining to their solubility and stability [ 25, 26, 40].
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