Sentence examples for difficulties of targeting from inspiring English sources

But officials concede the difficulties of targeting within the city are considerable.

Moghbel and colleagues also propose that there may be " inherent difficulties of targeting fibrillar amyloid plaques, which are not as well-defined as the soluble forms of the protein".

But on Wednesday Varoufakis pointed to the difficulty of targeting Greece's voracious oligarchs.

One additional reflection on sanctions experience has guided U.S. practice in recent decades – the difficulty of targeting an autocratic regime with broad sanctions.

The gold standard design would modify the environment and examine effects on activity, but existing environmental intervention studies in children, most of which focus on the school context, have produced mixed results [5] [8]; in part because of the difficulty of targeting the key environmental drivers.

The data presented in Figure 2 illustrates the difficulty of targeting busulfan exposures within a narrow therapeutic range.

Most of these disorders still lack an effective treatment, in part because of the difficulty of targeting the subcellular compartments in which mutant proteins accumulate.

These latter results were impossible to confirm using RT-qPCR because of the difficulty of targeting one specific transcript among multi-genic family transcripts.

Despite a reduction in malaria prevalence 68 the disease persists, possibly due to rapid urbanization, regular reintroduction, large numbers of breeding sites, a submicroscopic and/or asymptomatic parasite load, and the difficulty of targeting dormant stages of P. vivax.

The association of increasingly resistant candidal species causing candidemia and their associated worsened outcomes may be explained by the difficulty of targeting initial empiric therapy amidst the shifting landscape of antifungal susceptibility.

The first of the non-core modules, cell cycle, shows higher heterogeneity in all subtypes except in Luminal A. This module highlights the clinical difficulty of targeting the cell cycle with cytotoxic agents due to most tumor's high heterogeneity.