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The lack of spontaneous use of the paretic hand is primarily caused by difficulties of planning the hand trajectory in space, as reflected by temporal and spatial parameters during task performance.
Several major variables compound the difficulties of planning the best treatment regime and of designing clinical trials for testing chronic wound therapeutics.
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"It has been a bit of a challenge because the locations and the directions that people are expected to flee to have kept changing," said Alun McDonald, spokesman for Save the Children in Iraq, referring to the difficulty of planning for such large-scale movement.
This article highlights the difficulty of planning such wireless networks for indoor environments.
This algorithm can not only greatly expand the gait patterns of turning, but also reduce the difficulty of planning.
Holloway (1999) noted how arable farmers stressed the long timescales involved and difficulty of planning for unpredictable local climatic changes, as well as a certain amount of scepticism regarding the existence of climate change.
How do you communicate the difficulty of planning 79 weddings for total strangers.
The reason for this may be the difficulty of planning an adequate study design.
This is due, in part, to the difficulty of planning similar in vivo experiments, considering the fast bacterial doubling time in vivo, different biodistribution, affinity and specific activity of radiopharmaceuticals. Overall, we lack basic studies to clearly prove the mechanism of action and binding of these radiopharmaceuticals to bacteria.
Homeowners and estate managers on the sites included in the protected areas are anxious about possible restrictions (e.g., on carrying out renovations or other projects or changes in the use of the land), owners of plots for development perceive difficulties in, restrictions on, or refusal of, planning permission.
To these arguments we can now add evidence of the difficulty of reliably planning studies around a primary endpoint of OS.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com