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This qualitative systematic review of the clinical methodology used in randomised, controlled trials of oral opioids (morphine, hydromorphone, oxycodone) for cancer pain underlines the difficulties of good pain research in palliative care.
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In contrast, the difficulty of good writing is a difficulty meant to make the reader pause and rethink.
Duncan Bannatyne, Tony Hadley and Lady Colin Campbell are all going to have the same problems: the creaking of ageing joints first thing in the morning and the difficulty of good hair in humid conditions.
However, it is totally possible to assign amounts of homework that are reasonable in length and difficulty, of good quality, compatible with healthy sleep habits and plenty of family time and which still quickly and effectively turn students off even to minimally school-like educational activities.
In any case, this is just one study, and POGO does include caveats about the difficulties of collecting good salary data.
Cayley described the difficulties of retaining good staff under such financial uncertainty, "especially in Cambodia where it is quite a challenging environment to work in".
Ms. Brown noted one of the central difficulties of keeping good teachers in the system by adding, "We could waste our time training you for two years, then you want to go to Scarsdale and take our training with you".
Defense Secretary Donald H. Rumsfeld has acknowledged that the United States might have killed or wounded friendly Afghans in the raid on the two compounds, and in doing so he offered an insight into the difficulties of gathering good information: "In Afghanistan, people who are friendly and unfriendly are constantly meeting together.
This finding, coupled with the difficulties of maintaining good respiratory etiquette in young children, is a plausible explanation for the effect of child number on infection risk.
If you're having difficulty thinking of good things about yourself to focus on, ask your friends, family or teachers what they like about you or how you look.
Few Palestinians can leave their homes to work, and the costs and difficulties of transporting goods have become prohibitive, aid workers say.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com