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However the realistic model has some limitations including long calculation time and difficulties of generating a suitable mesh.
Since only a small number of anergic cells can move to the secondary lymphoid organ, the difficulties of generating bNAbs are far-reaching.
The evaluation was restricted to non-attenuation corrected images and reconstruction without collimator detector response compensations because of difficulties of generating DICOM images with the required header information for each gamma camera vendor.
Masks are a problem first because of the difficulties of generating a pattern with better than 10 nm tolerance on short range (<1mm) edge placement precision and with dreedom from defects, and of providing a pellicle to maintain a defect-free mask pattern.
Excellent outcomes notwithstanding, hESC-based screening platforms are limited by the difficulties of generating homogeneous and lineage-specific differentiated populations from hESCs while culturing them in large numbers for prolonged periods.
Work with these models has highlighted the difficulties of generating and implementing evidence on care integration.
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Google has since acknowledged the difficulty of generating revenue from social network advertising.
Here in this work, the difficulty of generating a preliminary discrete layout of a large number of heliostats is addressed.
Since only a small number of anergic cells can move to the secondary lymphoid organ, the difficulty of generating bNAbs cannot be understated.
It is however limited by the difficulty of generating sufficient amounts of CTLs in vitro, especially for the treatment of solid tumors.
However, practical implementations of these approaches are still scarce, with a key limitation being the difficulty of generating a range of plausible future time series of hydro-meteorological data.
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