Sentence examples for difficulties of further from inspiring English sources

Triplet regimens consisting of the combination and cisplatin or capecitabine in advanced solid tumors exhibited prominent toxicities suggesting difficulties of further developments of triplet regimens [ 28, 29].

Viscose fiber wastewater also contained a lot of insoluble large molecular organics, thus leading to the difficulty of further degradation.

Unfortunately, most of our patients initially received ineffective empiric antibiotics, including extended-spectrum cephalosporins, which increased the difficulty of further treatment and led to a high treatment failure and mortality rates.

The frustration born of the difficulties of securing further autonomy has also fuelled the Catalan independence movement, with polls placing support at between 30 and 50%.

The difficulties of identifying further genes by linkage indicate that the remaining genes might be numerous, with relatively common alleles conferring moderate risks.

The debts have since been cleared, but the Robins have confirmed the new agreement has been amended in the light of their difficulties to "further protect Cheltenham".

The ruling that overthrew California's Proposition 8 may be allowed to stand unscathed, thanks to a nest of legal difficulties and fears of further setbacks by opponents of gay marriage.

In general, regular radiotherapeutic follow-up examinations in patients with metastasized MM could be challenging for example due to a decline in performance status caused by progressive disease, long distance to the radiation clinic or organizational difficulties in case of further treatments elsewhere.

A slow growth of the hydrate phase inside the film reflects not only the moisture stability of the terpineol-modified perovskite but also the hydrate phase at the sub-surface can reach equilibrium with both the water vapor at the top surface and the inner perovskite phase resulting in difficulty of the further growth of hydrate compound.

This aimed at identifying a potentially imbalanced distribution of item difficulties, allowing the development of further items for respective difficulty levels.

Despite the technical difficulties of such studies, further investigation of TRPC modulation by lipids will be important.