Considering that sequence variants in the noncoding region may also affect the regulation and function of genes and the difficulty of functional characterisation of various CYP1B1 isoforms in vitro, analysing multiple SNPs simultaneously may provide more direct evidence for the relationship between cancer risk and the genetic polymorphisms in CYP1B1.
When the uniseqs were queried against the nr protein database, about 76.2% of them had no significant homology with proteins of known functions, which may be related to the difficulty of functional characterization of genes in rust fungi.
Large bone defect treatment represents a great challenge due to the difficulty of functional and esthetic reconstruction.
The second issue is that few neurons actually mature in the lesion, which would account for the difficulty of functional recovery after ischemic injury.
The Gene Ontology (GO) addresses the difficulty of functional classification for gene products, and has become the main resource for capturing such information in a controlled format that can be effectively used for search and computational analysis (1, 2).
Keeping an asthma diary as an alternative source of information also caused difficulties because of functional illiteracy and language barriers.
Difficulties with performance of functional activities may result from cognitive and/or physical impairments.
For this study chronic presentation of PTSD has been defined as being exposed to two or more traumatic events, the presence of comorbid mental health difficulties and evidence of functional impairment.
A new debate over the costs and benefits of deploying the military reflects the length of the conflicts in Afghanistan and Iraq, the difficulty of building functional governments and the financial burden at home in a time of extreme fiscal pressure.
To overcome the difficulty of adding functional groups to PCU, we explored various surface modification methods, and determined that plasma treatment was the most effective method to modify the graft surface with functional amine groups, which were subsequently employed to conjugate heparin via end-point immobilization.
