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The difficulties of design and construction of miniaturized blood pumping systems and the high costs associated with developing, testing, and approval of such devices has been prohibitive.
The main reason is three fold: inhomogeneous requirement, function and form definition in the general design context, ill nature of function-to-form mapping and difficulties of design synthesis with qualitative information.
However, difficulties of design, synthesis and validation of these nucleases remained an obstacle to widespread applications.
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At this level, the book is a fascinating account of the difficulties of designing laboratory experiments to dissect unambiguously something as complex and variable as behavior -- even the behavior of a fish with a brain the size of a pinhead.
The switch to arms reduction suggested that Reagan's critique of MAD had concluded with the view that, given the difficulties of designing and deploying both discriminating offensive options and effective ballistic missile defenses, it was better to do away with nuclear weapons altogether.
One also observes the constant difficulties of designing sustainable schemes for bus companies.
This highlights the difficulties of designing a regional or local climate policy.
This brief historical reminder highlights the main difficulties of designing terminological resources for radiology in general and structured reporting in particular.
This design takes advantage of existing TES technology while overcoming the difficulties of designing spatially large arrays.
Difficulties of designing exterior of the sampling system lie in the fluid dynamics performance of the system.
The difficulties of designing a delivery vehicle capable of delivering multiple factors whilst maintaining distinct release kinetics will be highlighted.
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