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Other limitations relate to the difficulties of demonstrating the 'impact' of patient involvement.
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Gillian Triggs, the president of the Australian Human Rights Commission, told the Senate a bar on proceedings would make it "virtually impossible" to bring forward any action, because of the difficulty of demonstrating bad faith in legal proceedings.
Ramus was aware of the difficulty of demonstrating his natural method in literature.
However, this opportunity may be limited by several factors: the spontaneous interconversion of the two enantiomers, the pharmacokinetic profile or the selective toxicity of the most active enantiomer, and the difficulty of demonstrating the clinical superiority of one enantiomer over the racemate.
Health promotion specialists are often frustrated by difficulty of demonstrating effects of their educational efforts.
One main reason for this situation has been the long-standing difficulty of demonstrating intercisternal continuities in thin sections for electron microscopy.
Furthermore, the results of the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) study (34) showed the difficulty of demonstrating beneficial effects of intensive glycemic control on CVD prognosis.
This illustrates the difficulty of demonstrating that a major cardiac event has been provoked by acute hypoglycemia in any individual diabetic patient, since simultaneous glucose and ECG monitoring is rarely possible in clinical practice.
The excellent pro/con debate by George and Morris [ 48] in Critical Care clearly summarizes both the robust evidence to support the implementation of ASP and the difficulty of demonstrating a real impact in terms of reduction of length of stay or mortality.
28 Given the absence of effect of the interventions on MSSA, the decline in MRSA prior to interventions, the strain specificity of the effect on MRSA and the difficulty of demonstrating the effect of an intervention package on MRSA isolation, 14 we find it difficult to estimate how much, if any, of the observed decline in MRSA isolations is attributable to recent infection-control measures.
He makes light of the formidable difficulties of Canteyodjaya, demonstrates that the Four Studies are much more than dry technical exercises and grades and minutely colours every strand of the aural landscapes that make up the Catalogue.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com