Mr. Carroll, who edited the paper from 1979 to 1991, said he was just trying to underscore the difficulty of correcting major mistakes.
However, given the difficulty of correcting misconceptions through traditional teaching methods or self-teaching (Morrison and Lederman 2003; Nelson 2008), we feel that the gains or stasis in student scores are likely due to the strengths and shortcomings of our software.
The resolution obtained by averaging ∼4000 particle subvolumes was ∼35 Å, most likely limited by the inherent flexibility of the complex (Burkhardt et al., 2011) and the difficulty of correcting precisely the contrast transfer function (CTF) for thick specimens.
Vaux writes, "Little did we know that instead of providing an answer to transplant rejection, these experiments would teach us a great deal about editorial practices and the difficulty of correcting errors once they appear in the literature" (Vaux, 2013).
Due to the current difficulty of simply correcting for multifunctionality, our focus has been on how to control for it.
The use of a relative standard has the advantage of correcting for variations in test-difficulty.
We acknowledge that ORF fragmentation can introduce other biases into comparative analyses, e.g., due to the increased difficulty of correct ORF modeling [ 14] or potentially, misannotation due to the lower informational content of ORF fragments relative to full-length sequences.
Also, some rRNA, tRNAs and SRPs were absent in the final set due to difficulties of producing correct genome alignments for these regions, which is critical for secondary structure prediction with RNAz.
For the grass surface, the scaling procedures resulted in a poorer performance of the 3T model (NSE decreasing from 0.74 to 0.70), which was attributed to effects of shading and the difficulty to correct for differences in emissivity between dead and living biomass.
The expense and practical difficulty of detecting and correcting random errors must be considered in relation to the benefits of such efforts.
