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Some of these studies have used the WHO's International Classification of Functioning, Disability and Health ICFF) [ 9] as the framework for describing psychosocial difficulties of brain disorders, which in the ICF are called "disabilities" [ 10- 14].
There is, however, at least one coordination action at the European level currently being carried out to address the changes in psychosocial difficulties of brain disorders over time (PARADISE http://www.paradiseproject.eu).eu
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Since the ICF is an etiologically neutral classification, it has the great advantage that it can be used for describing the psychosocial difficulties of any brain disorder.
This is because of several diagnostic difficulties: the symptoms of brain microabscesses can be vague and fleeting, and such symptoms can be difficult to distinguish in gravely ill sepsis patients [ 2].
In previous work linking task difficulty and modulation of brain activity in the intrinsic system, the difficulty manipulations pertained to perceptual processing demands such as stimulus discrimination or stimulus presentation rate (e.g., [54], [55] rather than to response selection demands.
Concussion settlement highlights difficulty of proving brain damage.
Early network oscillations could not be examined in our studies due to the difficulty of detecting brain activity in mice expressing the mtGA probe.
Another problem in devising treatments for neurodegenerative diseases is the difficulty of reversing brain damage that has already occurred.
A laudable future goal would be to validate these findings in a larger cohort; however, the inherent difficulty of obtaining brain metastasis tissues remains an obstacle.
Recognizing the difficulties of obtaining normal brain tissue from children, we utilized the normal fetal brains and normal adult cerebral RNAs that were commercially available as references.
Our clinical experience teaches us that the psychosocial difficulties of persons with brain disorders fluctuate with the stage of the disease, not infrequently over short periods of time.
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