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However, membrane proteins are one of the most understudied groups of proteins in biochemical research because of technical difficulties of attaining structural information about transmembrane regions or domains.
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By E. B. White The New Yorker, September 27 , 1930 P. 17Difficulty of attaining happiness in the hurried life of the city.
Almost every defender of absolute pacifism recognizes the difficulty of attaining to the absolute idea.
However to follow the path of active binocular vision, the difficulty of attaining fixative capabilities is of primary concern.
Despite rapid progress, the field continues to face many challenges at this time, including the difficulty of attaining fully differentiated and functionally competent β cells, either in vitro or in vivo.
Due to the difficulty of attaining optimal conditions for the above aspects of entrepreneurship, resilience is something desirable but hard to achieve for entrepreneurs (Sullivan-Taylor and Branicki 2011), and entrepreneurship is even regarded as an "extreme" experience (Schindehutte et al. 2006).
Bayer had begun to search for his mother in the 1990s, but the difficulty of attaining records in Ireland and the lack of cooperation from the nuns connected to the home where he was born stalled his progress.
Due to the difficulty of attaining ample specimens from early stage patients, preliminary study of early stage PC diagnosis through PBMC expression analysis may be first carried out in a spontaneous PC murine model which recapitulates the preneoplastic and early neoplastic processes seen in human PC as a proof of concept [31], [32].
Many stories told by the GPs described the difficulty of attaining this balance.
This illustrates the difficulty of attaining treatment targets in patients with ESRD, who frequently have comorbid conditions such as diabetes and hypertension.
These data suggest that thorough and reliable surveillance of melanoma patients is, in reality, hardly possible because of the often erratic and unpredictable course of the disease and because of the difficulty of attaining full patient compliance.
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