Other prominent concerns for these biologic drugs included a lack of long-term data (24%and29%9%), safety/tolerability (22% and 20%), and difficulty of administration (38%and13%38%and13%
In the case of adalimumab and infliximab, respondents cited a number of reasons not to prescribe these treatments, including cost, insufficient long-term data, concerns with safety and tolerability, and difficulty of administration.
Primary reasons not to prescribe a treatment were effectiveness for azathioprine, safety/tolerability for cyclosporine and cyclophosphamide, and a mixture of cost, safety/tolerability, and difficulty of administration for the biologic drugs.
Other contributing factors may include improper dosage regimen during administration which includes difficulty of administration of drops of antibiotics in day time use for adult populations and children [ 38].
90 Concern of hypoglycemia and of difficulty of administration should not prevent an elderly patient from enjoying the benefits of improved glycemic control with insulin treatment, for example improved quality of life and vitality.
Some possible mechanisms by which the above predictors could affect treatment include difficulty of drug administration in those below three years of age, the high prevalence of underlying malnutrition which increases the risk of infection, and chronic diarrhea which in turn decrease drug absorption and impair metabolism.
Pakistan's plummeting economy, the fragility of its democratic institutions, and the difficulties of the civilian administration in re-establishing normal government functions in cleared-up areas like Swat, need the attention of its western allies.
These included uncertainties as to the revenue that would be generated, and difficulties of enforcement and administration, which made this type of tax undesirable to recommend in their final report.
In case of administration difficulties, the content was to be put on a spoon and administered with a small amount of liquid.
CSI is an attempt in capturing the varying patterns of thought processes in a unitary scale that is psychometrically sound and overcomes the limitation of several other scales in terms of administration difficulty.
