Sentence examples for difficulties in trial from inspiring English sources

There have been only 3 drug approvals for NMIBC in the last 30 years, and product development for this disease has been stymied by difficulties in trial design and patient accrual.

The successful accomplishment of future H&N cancer treatment trials will need to acknowledge the increasing use of IMRT despite inherent difficulties in trial design and quality assurance.

There has been extensive analysis of screening mammography effectiveness (e.g. methodological difficulties in trial project and analysis, selective detection of certain types of tumours and breast cancer over-diagnosis) [ 9].

However, we know that one of the major difficulties in trials which randomise people to follow specific dietary patterns is that any particular diet cannot possibly suit every individual, which undoubtedly influences adherence.

A lack of validated measures of outcome and uncertainty regarding the appropriate disease states in which to test these agents have led to difficulty in trial design.

The fundamental problem has been difficulty in trial design with many of the challenges carrying over from clinical trials to clinical practice.

Trials with poor methodologic quality have exaggerated estimates of treatment effect, and incomplete reporting of trials causes difficulties in assessing trial methodologic quality.

Owing to the inherent difficulties in clinical trial design, few randomized double-blinded placebo-controlled trials for mitochondrial disease have been completed.

Schizophrenia presents unique difficulties in clinical trial design associated with the condition's variable presentation and clinical course, and multiple features influencing affect, cognition, volition and perception.

The 3-month lag was due to technical difficulties in completing trial registration.

There are particular difficulties in clinical trial design for this group of heterogeneous disorders with unpredictable clinical courses.