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The difficulties in substantiating the theory and practice of a second repentance were solved by Pope Calixtus (reigned 217?–217).
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Previous findings were helpful in substantiating this notion.
The dearth of studies reflects, in part, difficulties substantiating orthology relationships, which are complicated because plant genomes contain more duplicated genomic regions than animal genomes [ 19].
In the event, they had difficulties substantiating this claim and the judge held that there was no public interest in the publication of this material.
The 62 exclusions were due to small numbers of patients in the study, treatment of patients by surgery, difficulty substantiating the conclusions from the data provided, or absence of information on precise CR or PR rates.
Difficulties in cognition: a) as reported by self or informant, by history of treatment, or by clinician's report of decline; and b) substantiated by impairment on standardized mental status or neuropsychological tests of episodic memory, executive function, and/or attention, as defined by scores at a level of at least 1.5 standard deviations below appropriate norms.
The company had many difficulties in England.
"He had difficulties in literacy and numeracy.
Shells present particular difficulties in marine intercourse.
Indonesia also faces difficulties in America.
Difficulties in fact seem unavoidable.
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