In those centers with insufficient resources, the impact on patients was variable and ranging from longer waiting times for the first visit or follow-up visits to difficulties in respecting the exact schedule of drug administration leading, in a few cases, to the referral of patients to other centers for treatment.
That gives us particular difficulties, especially in respect of benefits while you are working - so called 'in work benefits'.
The BBC's difficulties in this respect mirror those of other public bodies.
The Proper Name Theory, Description theory, and Disquotational Theory, all seem to have particular difficulties in this respect.
The increased difficulties in this respect experienced by brain-injured patients with dysexecutive deficits together with the results of functional imaging studies point to the importance of the prefrontal cortex in mediating these capacities.
Alexandra Styron has no difficulty in this respect.
A difficulty in this respect, however, was that the meta-analysis of randomized controlled trials on LH versus AH [3] reported a much higher complication rate as compared with large prospective [4, 13] and retrospective case series [5, 14, 15].
Finally, cancer genome sequencing poses a particular difficulty in this respect, as the disease is caused by somatic mutations that may occur in a multitude of locations.
Discrepancies in reported frequencies should be attributed to the difficulty in strictly respecting the definition criteria especially concerning symptom duration (less than 4 weeks) and the definite exclusion of infection [ 3, 6, 36].
Identification of new viruses is particularly straightforward given the comparatively small size of viral genomes, but presents additional challenges due to the typical fast evolution of viruses resulting in difficulties with respect to the detection of homologous relationships.
