Sentence examples for difficulties in recapitulating from inspiring English sources

Given the apparent difficulties in recapitulating the in vitro effects in vivo, however, researchers should be cautioned and should remain critical concerning the use of MSCs for the treatment of human autoimmune disease.

The severely reduced brain size observed in patients with Aspm mutations has been proven to have difficulty in recapitulating in animal models (Pulvers et al., 2010).

Furthermore, the reduced culture time and as yet unclear correlation of in vitro culture time points with in vivo development suggest that in vitro models may encounter difficulty in recapitulating aspects of long term chronic neurodegeneration.

Nevertheless, such approaches are inherently limited by the difficulty in accurately recapitulating the conditions experienced by wild yeast populations, as well as the incomplete detection of every phenotype that affects fitness.

This might be partly due to the difficulties associated with recapitulating a complex human syndrome in animal models.

Progress however has been hampered by the difficulties in producing human CLL xenografts and the absence of animal models that accurately recapitulate human CLL and that are suitable to be used as a platform for preclinical testing of new therapies.

However, owing to the difficulties in studying epithelia in vivo in mammals, there is an urgent need for model systems that recapitulate the complexity of the epithelia yet still enable experimental observation and manipulation.

To date, however, there have been difficulties in producing transgenic mice carrying profound pathogenic mtDNA mutations (5) (R.N.L., personal observation), and it has not been possible to completely recapitulate, in mice, all the symptoms of any form of neuronal disorder associated with mtDNA defects.

Shells present particular difficulties in marine intercourse.

Indonesia also faces difficulties in America.

Difficulties in fact seem unavoidable.