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The significant differences between these rhodopsin structures, the relatively low sequence homology between individual GPCRs, and some difficulties in rationalizing point-mutation data suggests that homology-based molecular modeling alone will not provide the accurate structural information on individual receptors required for ligand design and in silico screening.
The feeling that a patient admitted to the intensive care unit (ICU) should not be considered as a 'terminal patient' [ 2] produces difficulties in rationalizing the use of new and costly technologies in a situation where resources are scarce, such as the modern healthcare systems [ 3].
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Simon Riches, in an essay included in The Philosophy of David Lynch, has noted that the Red Room dream sequence is an example of the difficulty in rationalizing a priori knowledge the "lack of empirical evidence that ... a faculty of intuition exists" in the mind is here represented by the "nonphysical", dreamlike Red Room.
But the producers will be able to point to the ratings in rationalizing their programming choices.
University of Pennsylvania law and philosophy professor Claire Finkelstein writes in "Targeted Killing as Preemptive Action" about the difficulties of rationalizing targeted killing outside of the realm of typical combat between state actors.
However, the overall picture emerging from previous studies showed the difficulties on rationalizing the secretion levels and secretion efficiencies [ 36– 36].
Social exchange theory suggests that without shared beliefs about the probability and nature of fire risk, hazard, and the risk-reducing benefits of cooperation, owners may face difficulty rationalizing efforts to engage in potentially burdensome social relationships (Cropanzano and Mitchell 2005).
The party line from university presidents has always been that a playoff in college football would interfere with academics, spoil the regular season and professionalize a sport that is having difficulty rationalizing its vestiges of amateurism.
Individuals who suffered a recurrence of thyroid cancer after initial RAI treatment had difficulty rationalizing this outcome and sometimes assigned self-blame.
And still, these difficulties do not rationalize away her mistreatment of Hagar any more than white women's experiences of sexism absolve us of our unreliability in the face of racism.
Hem is frozen in rationalizing: the cheese was always here; it has to come back.
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