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Irregular payments to treatment supporters further contributed to difficulties in intervention implementation, and would need to be addressed if the programme were implemented more widely.
We compared the total scales of EORTC-C30 pretreatment and post treatment and there were significant differences in insomnia, constipation and financial difficulties in intervention group (p<0.05).
Similarly, teachers reported greater reductions in behaviour difficulties in intervention children than in control children at both three and six months (effect size −0.3).
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There are also fundamental difficulties in comparing interventions with diverse objectives, intervention targets, measurement methods, and outcomes.
Although the mdx mouse diaphragm muscle is a membranous structure and, therefore, presents difficulties in direct intervention, it was shown that stem cell implantation via local application to this muscle generated moderate muscle reorganisation.
Despite the availability of data on consumption and price elasticity [ 24, 25], price subsidies to increase fruit and vegetable consumption were not analyzed due to theoretical difficulties in calculating intervention costs in economic terms (since subsidies are transfer payments from the government to consumers).
There are also fundamental difficulties in comparing interventions with diverse objectives, measurement methods and outcomes.
Due to the difficulty in conducting intervention studies, it was replaced with natural experiments [ 1].
Reasons for this are due to the complexities surrounding maltreatment and psychological disorders [ 14] and difficulty in demonstrating intervention effectiveness and cost-effectiveness [ 16].
Foreseen difficulties include: organizational and logistical difficulties in delivering the intervention, adjusting to government, political and policy changes, and maintaining timelines, as much as possible.
Prior studies of TSI during pregnancy and the postpartum period have experienced similar difficulties in implementing the intervention [ 17, 37, 38].
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