Providers' difficulties in estimating CHD risk should not be surprising, since accurate estimation requires integration of several different pieces of clinical information, some of which are categorical (smoking versus no smoking) and others of which are continuous (age, blood pressure).
Olanzapine was found to be less associated with EPS events than placebo treatment, causing difficulties in estimating the effect of olanzapine on EPS transitions and also causing model and estimation instability when analyzed simultaneously with the data from the other drugs.
Corporate executives have cited the difficulties in estimating charges for options as a reason why accounting regulators should not require the charges.
Difficulties in estimating the extent of assets the super-rich hold also prevent supporters of a wealth tax judging how much a levy would raise, it said, following HMRC's failure to publish data on the wealth of Britain's top 1%.
The difficulties in estimating the Earth system sensitivity, the paper points out, are due to "the lack of palaeo-analogues for the present-day anthropogenic forcing" as well as because "current models are unable to adequately simulate the physics of ice sheet decay and certain aspects of the natural carbon and nitrogen cycles".
One of the difficulties in estimating optical flow is bias.
Moreover, for larger bandwidths the GA has more difficulties in estimating the parameters of the approximation.
When applying the precautionary principle, industrial companies have difficulties in estimating the service lifetime of innovative materials such as aerogel.
Mobile sampling has difficulties in estimating long-term exposures for individual sites, but performs better for site groups.
There are two problems in solving (15): first, it is often not possible to compute in (8), due to the difficulties in estimating the genuine user PDF.
One of the main difficulties in estimating the CRF in a noise-robust way is that it is required that the weighting function is known.
