Yet, this problem is difficult for reasons closely tied to the difficulties in drug discovery itself, especially the diversity in biological target ligand interaction mechanisms.
This may be the key to overcoming the difficulties in gene discovery due to the genetic heterogeneity of susceptibility to individual cancers.
Part of the difficulty in drug discovery has been due to poor success of target-based high-throughput screening [12].
Much of the difficulty in TFBS discovery comes from the short length of the sequencing reads as well as their degenerate nature.
This analysis underlines difficulties in novel miRNA discovery, showing that different approaches are needed for complementarity.
In fact, such instabilities not only present difficulties in reproducible biomarker discovery, but also hamper exploring the clinical potentials of this technology.
Drop-in Discovery Station.
Despite the difficulties in interpreting the discoveries, astronomers are still trying to find more moons.
Difficulties in identifying legitimate targets and concerns about discovery limited their operations.
Insufficient "theory" support for the processes of discovery learning results in difficulties in generating and adapting hypotheses, designing experiments, interpreting data and regulating learning.
