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However, due to tremendous difficulties in developing highly selective inhibitors, most kinome targeted drug development programs restrict application to the oncology area [6].
Difficulties in developing some of its complex technologies have contributed to several years of delays.
It also points out the difficulties in developing drugs to treat autism and fragile X syndrome.
One of the difficulties in developing electric vehicles is the tradeoff between preserving battery power and delivering performance.
Earlier in the weekend he had pointed out the difficulties in developing an engine he described as both "aggressive" and "extreme" and after the race he was still looking forward.
The difficulties in developing the design and production specifications needed to produce low-cost bubble memory units severely tested the mettle of the R and D organizations in several companies in the United States, Japan, and Europe.
The research identified a series of "common criminological and socio-demographic characteristics" prevalent in offenders, which also included difficulties in developing personal relationships, a history of mental instability, a likelihood of switching hospitals frequently and a preference for nightshifts, presumably to minimise the likelihood of being caught.
Among other problems, officials blame technical and financial missteps, a rapid turnover among the bureau's information-technology personnel, difficulties in developing a system that is both secure and accessible to investigators, and, perhaps most critically, a resistance among some veteran agents who favor pens and pads over computers.
There are still difficulties in developing the game in competitive or challenging markets across a huge country, but the sense of holding one's breath around something fragile has eased and now the talk is generally of just how big the game can grow, and when.
In addition, some of the challenges and difficulties in developing common computational chemistry dictionaries are discussed.
Preschool children from economically disadvantaged families often experience difficulties in developing prosocial behavior.
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