Sentence examples for difficulties in confirming the from inspiring English sources

Despite the tremendous advances in molecular diagnosis of HNPCC that have been made since the discovery of genetic clues of this disease, the genetic etiology of many clinically defined HNPCC patients remains unsolved because of technical limitations and/or difficulties in confirming the pathogenicity of identified gene alterations [ 7].

The three origins of DUI for the taxa included in this study runs counter to the prevailing hypothesis of a single origin for this complex trait with subsequent reversals to SMI [ 23, 26- 28] but it is not unexpected given the bias toward "DUI absence" stemming from the difficulties in confirming the presence of DUI (e.g., [ 20, 25, 26, 54]).

Because of the difficulties in confirming the neurological diagnosis and in assigning the cause to SLE, we defined NP-SLE as (a) the presence of neuropsychiatric manifestations and (b) the elevation of CSF Ig indices [ 17, 18] and/or the elevation of CSF interleukin-6 (IL-6) levels [ 19].

Conventional backcross breeding has difficulty in confirming the several resistance genes combined in breeding lines using phenotypic selection with Xoo inoculation (Rajpurohit et al.2011; Shanti et al.2010; Sundaram et al.2008).2008

Because the resolutions of a lot of X-ray structures are not high enough, the hydrogen atoms and bond type information usually cannot be identified and even the coordinates have large errors, which bring difficulty in confirming the bond types of the structures.

The overwhelming interference from glutathione may be the cause of the difficulty in confirming the presence of cAMP by tandem MS under the experimental conditions used.

A common drawback of constructing shRNA vectors, irrespective of the method used, is the difficulty in confirming the sequence of the hairpin region using automated sequencing protocols.

However, the difficulty in confirming these birth-order differences is disconcerting.

As a result childhood TB is often neglected by TB control programs due to the difficulties in confirming diagnosis, over estimating the protective efficacy of BCG vaccine [ 4].

Overall, 75% of the insertion sites that failed to be confirmed had errors in the locus-specific primer design, suggesting that sequence errors or human errors were the primary causes for difficulties in confirming an insertion site.

The reluctance to include children in TB research studies may result from difficulties in confirming a diagnosis (due to paucibacillary disease and difficulty in obtaining specimens); such confirmation is often a prerequisite for treatment.