One major difficulty in computational modelling of HA-receptor binding is accurate representation of the receptors.
While difficulty in computational identification of functional small open-reading frames (smORFs; <100 codons) has led to their low representation in genome annotations, increasing evidence supports functional smORFs in eukaryotes [ 50, 51].
Similar to earlier studies (Badis et al., 2009; Jolma et al., 2013), a relatively low success rate was observed for C2H2 zinc fingers and basic helix-loop-helix proteins, probably at least in part due to difficulty in computational identification of DNA-binding zinc finger proteins, and the fact that many bHLH proteins bind to DNA as obligate heterodimers.
Finally, distribution of resources with SADI may act as a form of insurance against computational resources being lost into oblivion as a result of changes in platform popularity or difficulties in porting computational resources across platforms, since SADI services expose a standard, platform-independent interface.
Application of this method makes it possible to quantify the degree of difficulty involved in computational scaffold hopping exercises.
The technique can be applied to other neuron models, and not necessarily for planar systems; n-dimensional systems would only require an additional computational difficulty in computing the associated ( n − 1 ) ARFs.
Because of the computational difficulties in estimating large phylogenies, many computational biologists think that the only feasible strategy to estimating the Tree of Life will involve a divide-and-conquer approach where trees are estimated on subsets of taxa and a computational method is used to assemble a tree on the entire taxon set from these smaller trees.
Dennett suggests that part of the reason we may have difficulty replicating pain in computational systems is because our concept is so defective that it picks out nothing real.
In addition, some of the challenges and difficulties in developing common computational chemistry dictionaries are discussed.
When compared to the implementation of SLAM in 2D environments, airborne implementation imposes several difficulties in terms of computational complexity and loop closure, with high nonlinearity in both vehicle dynamics and observations.
