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"The circumstances that have led to the difficulties in Central Falls may actually be widespread," said Christopher W. Hoene, director of research for the National League of Cities.
The difficulties hit hardest in central Vietnam, the country's poorest region, where floods in December killed nearly 600 people and caused some $250 million in damage.
European leaders of the G-20, including German Chancellor Angela Merkel, British Prime Minister Gordon Brown and French President Nicolas Sarkozy, reportedly proposed increasing the $250 billion in resources already dedicated to crisis management to $500 billion at a meeting in Berlin, in light of difficulties recapitalizing banks in Central and Eastern Europe.
As the Alzheimer's Drug Discovery Foundation (ADDF) executive director Howard Fillit (ADDF, New York, NY, USA) pointed out in his opening remarks, major issues include the difficulty in drugging central nervous system targets and the predictability of AD animal models.
Therefore, although ESD en bloc resection, if possible, remains the treatment of choice [ 27, 28] our experience shows the feasibility of this combined ESD/EMR treatment to overcome the difficulty in dissecting central area of massive lesions, also considering the absence of neoplastic recurrence at follow-up and the post-operative complications detected.
Increasingly, officials have come to understand the provinces' difficulties in getting the central government to deliver services and money for local projects.
The settlement of large numbers of anarchic tribesmen in Egypt, with tribal ties and allegiances elsewhere in the empire, meant that Egypt often became embroiled in political difficulties with the central government.
We recognize that developing countries and countries with economies in transition face special difficulties in responding to this central challenge.
The back-and-forth underscored one of the central difficulties in resolving the crisis: while opposition activists and armed groups refuse to negotiate until the government stops its crackdown, Mr. Assad's government says it has the right to respond with force to armed attacks.
We recognise that developing countries and countries with economies in transition face special difficulties in responding to this central challenge.
The findings of this study demonstrate that one of the central difficulties in monitoring patient safety issues and preventing patient safety incidents for people with intellectual disabilities is the trend for reporting and monitoring those patient safety incidents that result, or could have resulted, in clearly defined physical harm.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com