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This very successful tradition seems to experience certain difficulties in application to complex systems in general, and to complex networks in particular, where it remains unclear if there exist some unique universal laws explaining a variety of structural and dynamical similarities found in many different real networks1,2,3,4,5,6,7.
All fractional derivatives have a lot of unusual properties that lead to great difficulties in application of fractional calculus.
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The standard C∗-algebraic version of the algebra of canonical commutation relations, the Weyl algebra, frequently causes difficulties in applications since it neither admits the formulation of physically interesting dynamical laws nor does it incorporate pertinent physical observables such as (bounded functions of) the Hamiltonian.
Dry deep-drawing is attractive toward zero emission of lubricants but it has great difficulty in application to metal sheets in general.
Current approaches to translocation detection have significant shortcomings, including limited sensitivity and/or specificity, and difficulty in application to formalin-fixed paraffin-embedded (FFPE) clinical samples.
Traditional approaches to translocation detection have significant limitations, including low sensitivity and/or specificity, and difficulty in application to FFPE clinical samples.
Failure to achieve the targeted glucose levels reflects the difficulty in application of clinical protocols to real-world practice, outside the rigid confines of RCTs, and has been recognized previously [ 35- 37].
A difficulty in application of ESI-MS to biological samples is the negative impact of salts on the method, and salt removal is therefore an important part of ESI-MS workflows.
The lack of an independent reference test is a common problem in studies that seek to validate the diagnostic application of new '-omics' based technologies and it contributed to difficulties in the application of the QUADOMICS items that refer to the reference standard.
Nevertheless, traditional data mining techniques find difficulties in their application on current scenarios, due to the complexity previously mentioned.
The main difficulties in the application could be identified through theoretical comparison and through a case study.
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