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Some advocates of the vaccine argue that logistical difficulties, great expense, and ethical concerns make randomised trials unsuitable for resolving the pneumococcal vaccine controversy [ 34].
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At times of great difficulty, great things must be done.
Because I believe at times of great difficulty, great things can still be done.
I believe at times of great difficulty, great things can still be done.
Note that this estimation problem is an order of difficulty greater than that typically encountered in biostatistics where the doses are known.
Such as: no difficulty = 0, slight difficulty = 1, moderate difficulty = 2, great difficulty = 3, extreme difficulty = 4. 2.
As Li and others urged Hu, "The greater the difficulties, the greater the need for democracy".
He felt, on the contrary, that the greater the economic difficulties, the greater the need for social justice".
Temporary difficulties are great opportunities for self-reflection.
Their difficulties appear greater than those of younger students in English-medium contexts.
These difficulties are greater for health workers outside research settings involved mainly in routine care [ 13].
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