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These characteristics make the studies of CAR activation extremely challenging and pose major difficulties for evaluating drug-mediated CAR activation in vitro.
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For the Ile-de-France, the limited number of regional hospitals does not appear to present a difficulty for evaluating performance.
A difficulty for evaluating the incorporation of resources from mixed diets is that the isotopic signature may not exactly correspond to the signature of the food resource (see [ 24, 25]).
Partly due to the difficulty of evaluating qualities for PPI data, a majority of widely-used PPI databases, including DIP, BIND, MINT, HPRD, and IntAct [ 11, 19- 22], take a "conservative approach" to PPI data expansion by adding only manually curated interactions.
American political discourse has grown more simplistic for decades, at least according to the Flesch-Kincaid reading-level formula, a gauge widely used by publishers and educators for evaluating the difficulty of a text, according to the length of its words and the complexity of its sentences.
For evaluating the difficulty of an item, it is helpful to consider the likelihood of guessing the correct answer.
Since the performance of different algorithms depends on target difficulty, taking this characterization into account becomes essential for evaluating predictions.
However, this is not the case for the attribute "perceived amount of reverberation", illustrating the difficulty of evaluating this attribute.
Frustrated with the difficulty of evaluating technology companies' R&D spending, many institutional investors have opted for a "dartboard strategy".
Attempts to follow up this hidden and hard-to-reach population for evaluating the effectiveness of interventions face methodological difficulties.
The difficulty with this is that there are no independent standards for evaluating leadership.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com