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In view of the difficulties for applying the common-used microarray analysis methods such as t-test, SAM, and FDR for small sample size experiment, Chen and his colleagues [ 2] proposed a model-based information sharing method (MBIS) that enhances the power of statistical test by utilizing information shared among genes.
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Consequently, the difficulty for applying the ICA algorithm under the conditions that the sensor number is limited and the source number is unknown can be successfully eliminated.
In practice, the difficulty of applying for patents for designs and utility models is relatively low.
The boundary conditions used to represent macroscopic-gradient-related effects in arbitrary geometries with the lattice Boltzmann methods need a trade-off between the complexity of the scheme, due to the loss of localness and the difficulties for directly applying link-based approaches, and the accuracy obtained.
A good deal of criticism has been aimed at TTM, regarding, for example, the difficulty of applying the model to complex dietary behavior [ 3, 6– 11].
Mr. Johnson alluded to the difficulty of applying the Clean Air Act, designed for conventional pollutants like sulfur dioxide and nitrogen oxide, to greenhouse gases.
Finally, we present practical guidelines for applying this strategy considering several scenarios of increasing difficulty.
Some of these observations could be regarded as stereotypical and partial: the frequent tendency to blame time constraints for difficulties in applying reattribution in practice can be seen as an example of a 'culturally honourable' excuse, a means of mitigating responsibilities when behaviour is questioned [ 24].
This article reviews the strategies, performances, current progresses and difficulties in applying SVM for predicting various functional classes and interaction profiles of proteins and peptides.
But for other women, they complained about the difficulties faced in applying for the widow pension, such as travelling alone to the office and handling the administrative requirements.
The unaddressed issues include the specific target population that is most likely to benefit, the most effective and safe method for cooling, the optimal age at onset and duration of cooling, and the field difficulties in applying any specific method for cooling, particularly for outborn neonates [ 34].
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