But in 2012, shortly after a string of personal tragedies including a breakup, the sudden death of her mother, and several health difficulties culminating in a breast cancer diagnosis, she performed a stand-up set about her life that Louis CK called "masterful".
Despite financing difficulties, which culminated in one of the main backers dropping out, Soderbergh didn't let things get him down.
A plague epidemic in 1665 and the Great Fire of London in 1666 contributed to England's difficulties, which culminated in the destruction of its docked fleet by the Dutch at Chatham in June 1667.
After returning to England, he continued to advise the British government on colonial matters, calling for hardline responses to ongoing difficulties in Massachusetts that culminated in the 1773 Boston Tea Party.
Ventosa-Santàularia et al. associate a break in the innovation variance in July 1976 with macroeconomic difficulties in Mexico culminating in a shift from a fixed nominal exchange rate vis-à-vis the US dollar to a managed float in September 1976.
However, the Satake had political difficulties with the alliance, which culminated in the murder, in Akita, of a delegation from Sendai on August 21, 1868, and the display of the messengers' gibbeted heads in the Akita castle town.
The resulting friction had then culminated in A Squadron's difficulty linking-up with B Company in the dense vegetation, further delaying their relief.
Financial difficulties off the field and poor results on the pitch culminated in defeat away to Cesena on the last day of the 1989-90 season.
The scene before Game 1 of the N.B.A. Finals, against the Cleveland Cavaliers, was no exception, and it culminated, as always, after a series of shots of increasing difficulty, with Curry's signature volleys from the tunnel that leads to the locker room.
