Tensile testing has been shown to permit direct intrinsic determinations of tissue quality, but it was recognised by Black et al. [27] that this method of testing was associated with severe limitations, particularly with difficulties between bone clamp interfaces.
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Although a greater range of excision will decrease the likelihood of recurrence, extensive resection may increase the difficulty of bone and joint reconstruction.
Most MR-guided attenuation correction techniques ignore bones owing to the inherent difficulties associated with bone segmentation unless specialized MR sequences such as ultra-short echo (UTE) sequence are utilized.
"That, in turn, can cause flooding, because water has difficulty penetrating bone-dry earth.
The quantitative accuracy of brain PET/MR has been reported to be reduced compared to PET/CT due to difficulties related to bone in MR-based attenuation correction (MRAC), especially in regions near the skull.
Software-associated difficulties with automated bone and implant identification necessitate manual analysis in some cases, which inevitably leads to a reduction in precision (Spittlehouse et al. 1999).
While this compression represents a respectable force for such a simple technique that is commonly used for anterior fusion, the reduced contact area reflects the real-life difficulties of fitting bone grafts: cutting parallel lines that correspond with resection planes.
Difficulties in nasal bone examination experienced by our examiners were similar to those in nuchal translucency measurement, but nuchal translucency could be measured in either the prone or supine position of the fetus.
Methodological difficulties in nasal bone examination in the first trimester have been reported in the FASTER trial by Malone et al., in which well-trained sonographers who had little previous experience in evaluation of the nasal bone were able to depict the nasal bone in only 75.9% of 6316 fetuses [ 18].
