A notorious difficulty, applicable to white paint, is the overlap between Ti K-lines and Ba L-lines [21].
The FPQ contains questions (such as "To what extent did you have difficulty engaging in your hobbies during the last four weeks because of your illness?") for which there were six possible response categories (no difficulty, mild difficulty, moderate difficulty, severe difficulty, impossible, not applicable).
Though current high-throughput localization experiments provide valuable data, they are costly and time-consuming, and due to technical difficulties not readily applicable for many Eukaryotes.
Such large-scale experiments are both costly and time-consuming, and due to technical difficulties are commonly not applicable to higher Eukaryotes.
Such difficulties have now become applicable to some of the more frequently occurring childhood cancers, due to the discovery of molecular subgroups within tumor types 36, 37.
Nicol and Nielsen (2003) conducted a survey and a number of interviews in Australia, and the participants reported that they had rarely experienced difficulties in accessing broadly applicable research tools and technologies [ 11].
The sol-gel method has problems such as restricted applicable polymers, difficulty in using it for various industrial applications with constant quality.
BMV is an easy method, often applicable without difficulty by paramedics or even by laypersons.
One major methodological issue is the difficulty of finding universally applicable paradigms that can be standardized and that are ecologically valid for the species to be compared.
Indeed, a very recently published study by Gemer et al (2009) has underscored the difficulty to devise generally applicable models able to reliably predict surgical outcome in advanced ovarian cancer patients, across different Institutions.
