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As responses were coded, the sample size was gradually increased, until student difficulties appeared in a consistent manner and finally reached saturation.
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As Judge Hand observed, however, such line-drawing difficulties appear in all areas of the law.
An example of these difficulties appears in the first-act finale, in the coloratura leaps and runs negotiated by Lili Vanessi, a faded Hollywood star playing Shakespeare's Katharine.
Similar difficulties appear in appraising teams and institutions [4] [6].
In peptide design for MRM, the similar difficulty appeared in selecting multiple unique peptides of AKRs due to the highly homologous amino acid sequences in AKR proteins.
For example in the initial version of the AGQ, the word difficulty appeared in many of the questions (do you have difficulty with...?), as well as in the corresponding response options (no difficulty, a little difficulty, moderate difficulty, extreme difficulty).
The finding that the interaction between WM load and search difficulty appeared in distributed premotor and posterior but not prefrontal regions thus indicates that prefrontal and posterior regions may have different contributions to the limitations of the processes involved in WM.
This paper overcomes the difficulty appearing in using the standard reduction method to locate the concentrating points of the solutions.
LS in SM that do not appear in the currently selected LSC are incremented (reinforced), making them stronger, considering that the learning difficulties appeared because they were not present in the selected LSC.
Here, albeit in his archaic vocabulary, Bradley identifies in advance the difficulties which Russell was later to face in trying to reconcile the unity of the proposition with what he thought to be the mutual independence of its constituents, difficulties which appeared in another guise for Frege in his attempt to maintain a strict division between concepts and objects.
Difficulties appeared almost from the start, however.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com