You jump to conclusions, get stressed by minor difficulties and problems, and question yourself.
Beccaria's later years were beset by family difficulties and problems of health.
Born with a rare neurological condition, 19-year-old Joe Rae has learning difficulties and problems with speech and motility.
A life might be saved but a legacy is left that may include kidney and hearing problems, visual difficulties and problems with the thyroid and growth.
But even at equivalent blood alcohol levels, older people are more likely than the middle aged to experience intoxication, cognitive difficulties and problems with balance and coordination.
"We are clearly aware that there are still some outstanding difficulties and problems in China's economic and social life," he said.
Such incidents can arrest normal and healthy child development and result in symptoms like anxiety, depression, delinquency, learning difficulties and problems with interpersonal relationships, including parental ones.
"It was the beginning of the liberation of Europe that helped set up a post-war world which, for all of its difficulties and problems, has been unprecedented in terms of the prosperity of humanity.
It is important not to deny that there are many and varied difficulties and problems in doing a PhD, however, the risk is to make over-simplified explanations or causes.
Back in 2003, the then education secretary, Charles Clarke, found himself under attack when he argued against "a medieval concept of the university as a community of scholars unfettered by difficulties and problems of wider society".
"I'm the kind of person who is concerned about all the things and difficulties and problems that can occur," he said, sounding somewhat more measured than in recent days, "and we have spent a great deal of time thinking about them, analyzing them, preparing for them.
