Sentence examples for difficult when considering from inspiring English sources

At the same time, however, we would like to stress the fact that if this might be possible for quiet periods, it would become difficult when considering disturbed conditions, for which the calculation of monthly median values does not make sense.

However, parameter estimation becomes slightly difficult when considering regulatory relationships.

Because positive selection often occurs only during short stretches of evolutionary history, detection of statistically significant patterns consistent with past positive selection events can be difficult when considering average measures of selection among lineages.

Previous data from a human model of RA had suggested a role for TLR8 in the production of TNF [ 14]; however, extrapolating this finding across species becomes difficult when considering the role of TLR8.

Though graphical modeling provides a simple way to infer and visualize complicated networks among genes and gene products, estimating such networks can be very difficult when considering the impact of millions of variant-gene combinations.

In addition, although assessing the combined action of co-acting chemicals may be practically possible when they have the same basic mechanism of action (e.g., act on the same molecular target), the problem becomes much more difficult when considering chemicals that impact the same biological system but act through different mechanisms.

The implementation of inflammatory cytokines, however, proves to be difficult when considered for therapeutical approaches (Mountziaris et al. 2011).

Both models are already computationally difficult when considered separately, and combining them obviously represents a major computational challenge.

Kilwardby has such a desire to substantiate this unity that he finds himself in an extremely difficult position when considering what happens to the soul and the whole of its potentiae at the death of the body.

Crafting a universal disclosure is difficult, particularly when considering the complicated nature of small-business loan products.

The search for vascular substitutes has proven to be difficult, specially when considering small diameter grafts.