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Attaching a wooden-soled shoe to the fixator by Velcro to hold the ankle plantigrade has been tried but found limited success at our hospital; problems arose from the constant high pressure to the heel and the forefoot, which patients found difficult to tolerate for any period of time.
Treatments included chemotherapy (63.1%) and stem cell transplantation (38.9%) and were difficult to tolerate for 54.1% of respondents.
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Adjuvant chemotherapy reduces the risk of relapse but it also has side effects and can be difficult to tolerate, especially for older patients.
Current treatments are difficult to tolerate and do not substantially improve quality of life for most patients.
To date, the only available treatment is a combination therapy with pegylated interferon-α and ribavirin, which remains poorly effective for HCV genotype 1 infections, and is generally difficult to tolerate, leading to ≥50% therapeutic failures [reviewed in Ref. 1].
This study provides novel information about the cognitive associations that may underlie avoidant behavior in smokers, and may be important for understanding smoking relapse when negative affect states are particularly difficult to tolerate.
The injury is painful and incapacitating, and, for all but the most minor injuries, weight bearing is difficult to tolerate.
He shunned strong drink and tobacco and found it difficult to tolerate overindulgence in alcohol.
With a decaffeinated, empty stomach, and a thirst that is difficult to tolerate, this act of fasting connects me to someone else.
"It's admitting that you're not consistent with your self-concept, which is very difficult to tolerate," Lickerman told The Huffington Post.
Severely affected patients often find such treatment difficult to tolerate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com