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Until recently, the lack of lymph vessel-specific markers made it very difficult to specifically study BVI or LVI.
There are many factors that can cause bond failure of orthodontic brackets, including the multifactorial nature of the oral environment which causes pH fluctuations, as well as the complex cyclic loading of chewing, alcohol-containing fluids, temperature variations, and food consistency, all of which make it difficult to specifically determine the reasons for failure [6 9].
Furthermore, all these parameters are interrelated and it is difficult to specifically extract the relevant one.
It can be difficult to specifically pinpoint the cause of such discrepancies in studies using a range of real-world object categories.
Polo-like kinase 1 (Plk1) is an essential kinase that regulates spindle assembly, mitotic entry and chromosome segregation, but because of its many mitotic roles it has been difficult to specifically study its post-anaphase functions.
Although it is difficult to specifically test these hypotheses, information on the ecological and genetic correlates of variation in venom composition within species will enhance our understanding of the forces driving Conus venom evolution.
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The problem is that because the molecules are complex, and the target bonding sites are inert and difficult to modify specifically, even such a minor change can be difficult or impossible.
A major goal of drug discovery in recent years is the development of small molecules that target specific protein-protein interactions1, but there is a growing consensus that such targets are intrinsically difficult to perturb specifically with small molecules2.
Several models were proposed -- including expanding the system beyond the four marquee bowls -- but the presidents found it difficult to talk specifically about each scenario until they were discussed with conference commissioners and dissected by consultants specializing in television rights fees and bowl contracts.
This article showed that the regulator's requirements are difficult to achieve, specifically when sensing allowed time is limited.
Resilient leaders are perceived more positively in an organization, but it's sometimes difficult to understand specifically what a leader can do to be viewed as more resilient.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com