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That's what makes it very difficult to solve the problem.
It is notoriously difficult to solve the structure of GPCRs by crystallography.
In general, it is very difficult to solve the nonlinear partial differential HJII.
With multiple pointing constraints, it is greatly difficult to solve the constrained spacecraft reorientation planning problem.
However, it is difficult to solve the feasibility test problem for process models involving black-box constraints.
The introduction of backward diffusion and framelet regularization makes it difficult to solve the variational energy function.
Since the objective function is nonconvex and nondifferentiable, it is difficult to solve the original optimization problem directly.
It makes it more difficult to solve the problem because they are developing their own tactics". A senior member of his crew was less diplomatic.
In general, the GTEM cell is considered as the rectangular coaxial transmission line, it is difficult to solve the characteristic impedance using traditional analysis and semi-analysis method.
As it is difficult to solve the ILP problem within practical time, two heuristic algorithms are presented: Largest Traffic Demand First (LTDF) and a Random Selection (RS).
Since the complexity of such constraints and the switching instants is unknown, it is difficult to solve the problem by standard optimization techniques.
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