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Sollami-Covello also highlighted election administration issues, saying the short turnaround between Oct. 16 and Nov. 5 would make it difficult to reprogram election machines and secure polling places.
Methods to enhance the reprogramming efficiency would significantly increase the feasibility of this approach, especially for cell types which tend to be more difficult to reprogram, such as the primary adult human fibroblasts used in this study.
Further consideration and comparison of these studies is merited: First, it is apparent from several studies, including that of Silva and colleagues, that it is more difficult to reprogram somatic cells such as MEFs than neural stem cells [18], perhaps due to the state of differentiation of MEFs and/or epigenetic status of key pluripotency genes.
After that time point, the discs are difficult to reprogram.
Donor cells that are difficult to reprogram can be more efficiently induced into the pluripotent state by adding hTERT and SV40 large T antigen to the reprogramming factors originally used by Yamanaka's laboratory (Park et al., 2008).
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"It's going to be really hard to reprogram this guy for combat," Mr. Rosario said.
Latham theorizes transcription factors "are the most difficult genes to reprogram" when creating a clone.
The hard part is you got to reprogram them".
To reprogram our minds, we have to simulate difficult situations so that our brain is more comfortable with responding.
Analog devices are notoriously difficult to design and reprogram.
"And then it is not just enough to switch off the systems through a software attack, but you actually have to reprogram the system in order to modify outcome parameters and that is much more difficult.
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