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These opposing effects make it difficult to reliably diagnose bottlenecks from simple summary statistics of nucleotide diversity such as Fu's D (Fu and Li 1993) and Tajima's D (Tajima 1989).
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T2-weighted imaging alone lacks specificity and is insufficient to reliably diagnose local recurrence [36, 37, 41, 42, 43].
There are two key factors that have inspired and influenced efforts to reliably diagnose ASD in very young children.
Single symptoms and signs are rarely sufficient to reliably diagnose CHD.
This makes it difficult to reliably estimate changes over time for an individual tree.
This of course requires an Internet connection to work, which obviously made it difficult to reliably demo here at MWC.
The high burden of physical complaints and symptoms could make it difficult to reliably detect and diagnose depression in elderly multimorbid patients.
Yet it is surprisingly difficult to reliably produce exactly one photon.
However, it is still difficult to reliably detect when the target's body is almost occluded.
It was therefore difficult to reliably find the centre in the analysed tissues.
All of these problems make it difficult to reliably analyze the eye.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com