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It is difficult to reconstruct with certainty the size and shape of the probable keratinous sheath that would have covered each of the knob osteoderms.
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Internal branches of a phylogenetic tree frequently are difficult to reconstruct with confidence.
Thus, it is difficult to reconstruct sharp-edge profiles for DOT images with L2 regularization.
Once lost, it's difficult to reconstruct.
In addition, the evidence is often difficult to reconstruct.
If interest lies in a certain risk haplotype, for example haplotype 0010101 of CAPN10 (Figure 5), one does not have to worry about biased estimates since it is reconstructed with certainty although it is rather rare.
Although his life cannot be reconstructed with certainty, fragments have come from 4th- and 5th-century ecclesiastical historians.
It is difficult to say with certainty.
These things are difficult to count with certainty.
Sepsis can be difficult to diagnose with certainty.
Or is it, in truth, pretty difficult to say with certainty?
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