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In truth, however, whether these therapeutic approaches will indeed be sufficient to treat or prevent neurodegeneration in MPSII patients is difficult to predict at present.
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Hence, it is natural to assume that some part of noise is activity independent, even though the actual form of noise strength is difficult to predict at the present stage.
Other secondary structures, like triple helices for example, are difficult to predict bioinformatically at present.
The occurrence of cold intolerance is difficult to predict and when present it tends to persist for years.
At this stage, it is difficult to predict the role bacteria present in low numbers, play in nasopharyngeal ecology.
The Environment Agency said it was difficult to predict accurately at this stage exactly which businesses would be hit.
"Even with 20-20 hitdsight, it would have been difficult to predict this at the beginning of the quarter".
However, variation in the occurrence of parasitism makes it difficult to predict parasitoid colonization at a specific place and time.
What this means for the risk of flooding, however, will vary widely from location to location depending on local climatic changes that at present are difficult to predict with confidence.
The therapeutic agents for MDS still have unknown mechanisms, therefore, it is difficult to predict clinical responses by analyzing gene abnormalities at present.
At present it is difficult to predict how ADCC is caused by mutations in β-crystallins and experimental investigations are still necessary to elucidate the deleterious effects of these mutations.
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CEO of Professional Science Editing for Scientists @ prosciediting.com